How to download genetic/SNP data from UK Biobank - bioinformatics

For an approved research project, how to download the genetic/SNP data? The tabular data (demographics and clinical) has already been downloaded successfully, but the documentation does not really show how to download the corresponding SNP data. Any directions will be greatly appreciated.

You can check the documentation regarding that from the UKB in the questions 10-15 in the FAQ on that link to I think explain the process: (https://www.ukbiobank.ac.uk/media/cffi4mx5/ukb-genotyping-and-imputation-data-release-faq-v3-2-1.pdf)
In the table in the site below, I see some SNP data is available from UKB directly. I guess it depends what SNP data they are after: https://biobank.ctsu.ox.ac.uk/crystal/crystal/docs/ukbgene_instruct.html
I hope it helps to start!

It turned out to be well-documented here. Using gfetch, genotype data can be downloaded in PLINK binary format (.bed). Then it can be imported into R using packages such as genio and BEDMatrix.

Related

Why is there no access to all document resources?

I would like to understand why I can not continue my work with Carrot2. A message appears saying "Our apologies, the following processing error has occurred:
org.carrot2.source.etools.IpBannedException: org.apache.http.client.HttpResponseException: Forbidden"
There is a problem with eTools, Wiki, PUT document sources (31/07/19) into Online version. I try to work with the downloaded version of the programme, but no document source does not work. Could you solve this problem and how long it will take?
Thank you!
Please see here:
http://project.carrot2.org/faq.html#ipbanned
We provide the search interface as a demo of the technology and we use a partnership with a company called Comcepta (eTools) for providing a limited number of free search requests. Unfortunately, some people have been abusing this free service and we had to introduce per-IP limitations.
If you wish to extend your query limits please install Carrot2 locally and contact Comcepta for custom query limit arrangements.
Apologies for the inconvenience.

How can I index sub-community discussions and events?

I have written a custom crawler to index all the data from the connections seedlists
https:///forums/seedlist/myserver
When we started utilizing subcommunities, I double checked to make sure subcommunities behave practically the same as communities. They seem to, they have all the same properties in the Connections DB, just subs have a parent uuid. Got it.
I expected my crawler to find the sub communities discussions (basically just iterating through the atom feed with a Java XML parser) and pulling out the relevant information. Are subcommunities not published to this seedlist? If not, there does not seem to be a subcommunity specific seedlist.
We are currently on Connections 4.5
Thank you.
I have found the answer here.
http://www-10.lotus.com/ldd/appdevwiki.nsf/xpDocViewer.xsp?lookupName=IBM+Connections+4.5+API+Documentation#action=openDocument&res_title=Community_entry_content_ic45&content=pdcontent
There seems to be an additional element that links to the sub-community feed from within the community. A crawler will need to send a GET request to that link.

How to decode this png file?

Can anyone please help on how to open this png file: https://dl.dropboxusercontent.com/u/23248082/TEST.PNG
Also it would be great if you can tell me how it is enrcrypted or why its not opening.
It opens fine only with Meditech client. It seems Meditech is encrypting in someway.
I tried with different viewers and also tried converting it into differen format but so far no luck.
Iam also a newbie in this area. Any help would be highly appreciated.
Thanks..
Looking at it with tweakpng it seems the format is deliberately corrupted for proprietary use. There's a wrong CRC for the palette (correcting it does no good) and an invalid chunk count.
If your Meditech is the EHR (Electronic Health Record) system then you will only be able to accurately view the image by accessing it from the system. All data is encrypted for the purpose of restricting access to patient records.

Is there any tool to generate a labels.rdf file?

Examining the 404 errors for my website I noticed requests for a "labels.rdf" file. After some digging I think I understand what it is and want to create one for my website. But I don't really understand how to generate it. Is there any tool or a generic file that I can use?
Thanks
RDF is not just one format, but a collection - most likely it's expecting RDF/XML.
IMHO the esiest thing to do is create the data you need in a format called Turtle (http://www.w3.org/TeamSubmission/turtle/) - there's lots of tutorials online, then convert it to RDF/XML with a tool, such as rapper (http://librdf.org/raptor/).
You will need to know a bit about the RDF data model though, and what the labels.rdf file is trying to express.

How to access fsevents to get the file system events?

Though i had read the fsevents article provided by apple developer site, i m having issues in receiving the events. I need some samples to fetch events.
Need some samples.
Thanks in advance.
rgds,
herby
I'm in the middle of solving this and MacFSEvents looks promising (that is, if you're OK with using Python).

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